Endocrine Abstracts

Introduction: Increased adrenal androgen production is present in 20–60% of women with polycistic ovary syndrome (PCOS). Possible mechanism is not clarified yet and could be related to altered hypothalamic-pituitary-adrenal-axis (HPA) activity or a consequence of adrencortical steroidogenic abnormalities. The aim of the study was to assess HPA sensitivity in PCOS women using different doses of dexamethasone.Methods: We analyzed 359 women with PCOS d...

Paragangliomas (PGLs) and pheochromocytomas (PCCs) are rare neuroendocrine tumors that derived from pluripotent neural crest stem cells. PCCs are derived from the adrenal medulla, while PGLs are histologically identical tumors derived from ganglia outside the adrenal gland. Even though the majority of tumors are benign, they are associated with high morbidity rates caused by excessive catecholamine secretion. We retrospectively analyzed 71 patients (36 female and 35 males) wit...

Introduction: Calcitonin secreting neuroendocrine tumors (NET) are rare and not well recognized. Due to many similarities, it is sometimes difficult to differentiate them from medullary thyroid carcinoma (MTC), which can hamper choice of proper therapy. We investigated our group of patients with this type of NET in terms of diagnosis and biology.Patients and Methods: We analyzed 38 patients with calcitonin secreting NET (5% of all our patients with NET)....

Introduction: Recently, it was suggested that insulin resistance index using C-peptide (CIR) could be a better marker of insulin resistance than homeostasis model assessment (HOMA-IR) in patients with type 2 diabetes mellitus. The aim of this study was to investigate performance of CIR index in PCOS subjects.Methods: We evaluated 187 PCOS women (PCOS: 25.38±6.32 kg/m2; 26.01±5.16 years) diagnosed using ESHRE/ASRM criteria and 42 heal...

Introduction: It has been shown that subjects with normal fasting glucose (NFG) and normal glucose tolerance (NGT), whose plasma glucose concentration does not return to their fasting plasma glucose (FPG) level within 2 h following standard oral glucose tolerance test (OGTT), have higher risk of progression into type 2 diabetes (T2D) than NFG/NGT subjects whose glucose returns to FPG level after OGTT. Although the development of T2D during the life of woman with polycystic ova...

Introduction: Polycystic ovary syndrome (PCOS) phenotypes A and B are considered to be more hyperandrogenic in comparison to phenotypes C and D that are considered to be mostly reproductive. The aim of this study was to analyze distribution of androgens in different phenotypes in our PCOS population.Methods: We evaluated 365 PCOS women (PCOS:25.05±6.24 kg/m2; 25.48±5.21 years) diagnosed using ESHRE/ASRM criteria and 125 healthy women...

Introduction: PCOS women appear to have an adverse body composition (BC). The aim of this study was to compare BC in lean PCOS in comparison to controls and to assess possible metabolic consequences.Methods: We evaluated 150 lean PCOS women (BMI: 20.96±2.06 kg/m2; age: 25.50±4.52 years) diagnosed using ESHRE/ASRM criteria, and 39 lean BMI-matched healthy women (BMI: 20.33±2.16 kg/m2; age: 27.67±5.39 years). BC wa...

Most of adrenal incidentalomas (AI) are nonfunctional, although some of those demonstrate an autonomous subtle cortisol hypersecretion that could lead to increased risk for osteoporosis. Several polymorphisms of glucocorticoid receptor (GR) gene have been found to alter glucocorticoid tissue sensitivity. The aim of this study was toinvestigate whether subclinical hypercortisolism (SH) and BclI variant of the GR gene have an impact on bone mineral density (BMD) in wome...

Introduction: Prolonged exposure to stress has a modifying effect on activity of hypothalamo-pituitary-adrenal (HPA) axis. This is a protective adaptation aimed to diminish potential deleterious effects of chronic hypercortisolism, and to diminish effects of acute exposure to heterotypic forms of stress. Our aim was to analyze modes of cortisol response to acute physical stress in groups of different stress categories and sex.Subjects and methods: Study ...

Introduction: It has been shown that most women with polycystic ovary syndrome (PCOS) have increased adrenal androgen production, enhanced peripheral metabolism of cortisol and elevated in urinary excretion of its metabolites. Simultaneously, this increased cortisol clearance in PCOS was shown to be followed by a compensatory overdrive of the hypothalamo–pituitary–adrenal (HPA) axis. The aim of this study was to determine HPA axis sensitivity in women woth PCOS.<...